Phthalimide, a pharmacophore exhibiting diverse biological activities, holds a prominent
position in medicinal chemistry. In recent decades, numerous derivatives of phthalimide …

Alzheimer's Disease (AD) is a multifactorial progressive neurodegenerative disorder
characterized by memory loss, disorientation, and gradual deterioration of intellectual …

Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …

A series of benzamide-dioxoisoindoline derivatives 3 was obtained, starting from phthalic
anhydride and different benzoyl hydrazides 2, by ultrasound irradiation in water as solvent …

Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by a
progressive degeneration of the brain that leads to loss of memory and deterioration of …

Functionalization of 2, 1, 3‐benzothiadiazole (BTD) with thiols at C‐5 position remains low
explored. Moreover, the arylthiol‐substitutions at this position are also unexplored and can …

In this study, a series of compounds derived from 4-methoxy-1 H-isoindole-1, 3 (2 H)-dione,
potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as …

Background and purpose: Alzheimer's disease is considered one of the lead causes of
elderly death around the world. A significant decrease in acetylcholine level in the brain is …

Objective (s): To investigate the efficiency of a novel series of coumarin derivatives bearing
benzoheterocycle moiety as novel cholinesterase inhibitors. Materials and Methods …

Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two
major forms of cholinesterases (ChEs) is considered as the common approach for the …