Mitochondria are highly dynamic organelles that participate in ATP generation and involve
calcium homeostasis, oxidative stress response, and apoptosis. Dysfunctional or damaged …

Cardiovascular disease is a major leading cause of morbidity and mortality in the United
States and elsewhere. Alterations in mitochondrial function are increasingly being …

Prolonged mitochondrial permeability transition pore (MPTP) opening results in
mitochondrial energetic dysfunction, organelle swelling, rupture, and typically a type of …

Abstract Sirtuin 3 (SIRT3) is a mitochondrial NAD+-dependent deacetylase that regulates
energy metabolic enzymes by reversible protein lysine acetylation in various extracardiac …

Mitochondrial disease refers to a heterogenous group of genetic disorders that result from
dysfunction of the final common pathway of energy metabolism. Mitochondrial DNA …

The mitochondrial phosphate carrier (PiC) is critical for ATP synthesis by serving as the
primary means for mitochondrial phosphate import across the inner membrane. In addition …

Duchenne muscular dystrophy (DMD), the most common inherited muscular dystrophy of
childhood, leads to death due to cardiorespiratory failure. Paradoxically, mdx mice with the …

The mitochondrion relies on compartmentalization of certain enzymes, ions and metabolites
for the sake of efficient metabolism. In order to fulfil its activities, a myriad of carriers are …

Background: The prognosis of patients with idiopathic dilated cardiomyopathy (DCM) has
improved remarkably in recent decades with guideline-directed medical therapy. Left …

Mitochondrial dysfunction is considered as a crucial contributory factor in cardiac pathology.
This has highlighted the therapeutic potential of targeting mitochondria to prevent or treat …