Quantitative preclinical PET imaging: opportunities and challenges

C Kuntner, D Stout - Frontiers in physics, 2014 - frontiersin.org
PET imaging of metabolism involves many choices, from hardware settings, software options
to animal handling considerations. How to decide what settings or conditions to use is not …

Advances in preclinical PET

SS Adler, J Seidel, PL Choyke - Seminars in nuclear medicine, 2022 - Elsevier
The classical intent of PET imaging is to obtain the most accurate estimate of the amount of
positron-emitting radiotracer in the smallest possible volume element located anywhere in …

Flash scanning volumetric optoacoustic tomography for high resolution whole‐body tracking of nanoagent kinetics and biodistribution

A Ron, SK Kalva, V Periyasamy… - Laser & Photonics …, 2021 - Wiley Online Library
Tracking of biodynamics across entire living organisms is essential for understanding
complex biology and disease progression. The presently available small‐animal functional …

Impact of a multiple mice holder on quantitation of high-throughput MicroPET imaging with and without Ct attenuation correction

F Habte, G Ren, TC Doyle, H Liu, Z Cheng… - Molecular imaging and …, 2013 - Springer
Purpose The aim of this study is to evaluate the impact of scanning multiple mice
simultaneously on image quantitation, relative to single mouse scans on both a micro …

The motivations and methodology for high-throughput PET imaging of small animals in cancer research

N Aide, EP Visser, S Lheureux, N Heutte… - European journal of …, 2012 - Springer
Over the last decade, small-animal PET imaging has become a vital platform technology in
cancer research. With the development of molecularly targeted therapies and drug …

High-throughput multiple-mouse imaging with micro-PET/CT for whole-skeleton assessment

M Yagi, L Arentsen, RM Shanley, SK Hui - Physica medica, 2014 - Elsevier
Recent studies have proven that skeleton-wide functional assessment is essential to
comprehensively understand physiological aspects of the skeletal system. Therefore, in …

Animal PET scanner with a large field of view is suitable for high-throughput scanning of rodents

Y Tomonari, Y Onishi, F Hashimoto, K Ote… - Annals of Nuclear …, 2024 - Springer
Objective In preclinical studies, high-throughput positron emission tomography (PET)
imaging, known as simultaneous multiple animal scanning, can reduce the time spent on …

Scatter characterization and correction for simultaneous multiple small-animal PET imaging

R Prasad, H Zaidi - Molecular imaging and biology, 2014 - Springer
Purpose The rapid growth and usage of small-animal positron emission tomography (PET)
in molecular imaging research has led to increased demand on PET scanner's time. One …

NEMA NU 4-optimized reconstructions for therapy assessment in cancer research with the Inveon small animal PET/CT system

C Lasnon, AE Dugue, M Briand… - Molecular Imaging and …, 2015 - Springer
Purpose We compared conventional filtered back-projection (FBP), two-dimensional-
ordered subsets expectation maximization (OSEM) and maximum a posteriori (MAP) NEMA …

Evaluation of the metabolic response to cyclopamine therapy in pancreatic cancer xenografts using a clinical PET-CT system

H Kayed, P Meyer, Y He, B Kraenzlin, C Fink… - Translational …, 2012 - Elsevier
OBJECTIVES: We analyzed the effects of anti-hedgehog signaling on the 18 F-FDG uptake
of pancreatic cancer xenografts (PCXs) using a clinically implemented positron emission …