A new family of luminescent iridium complexes: synthesis, optical, and cytotoxic studies

G Millán, M Nieddu, IP López, C Ezquerro… - Dalton …, 2023 - pubs.rsc.org
By using N, N-dibutyl-2, 2′-bipyridine-4, 4′-dicarboxamide as a diimine (dbbpy) and
distinctive cyclometalated groups, this work reports a new family of cationic phosphorescent …

Design, synthesis and investigation of the mechanism of action underlying anti-leukemic effects of the quinolinequinones as LY83583 analogs

HI Ciftci, N Bayrak, M Yıldız, H Yıldırım, B Sever… - Bioorganic …, 2021 - Elsevier
Literature conclusively shows that one of the quinolinequinone analogs (6-anilino-5, 8-
quinolinequinone), referred to as LY83583 hereafter, an inhibitor of guanylyl cyclase, was …

Luminescent cycloplatinated complexes with biologically relevant phosphine ligands: optical and cytotoxic properties

G Millán, N Giménez, R Lara, JR Berenguer… - Inorganic …, 2019 - ACS Publications
Two series of neutral luminescent pentafluorophenyl cycloplatinated (II) complexes [Pt (C^
N)(C6F5) L][C^ N= C-deprotonated 2-phenylpyridine (ppy; a), 2-(2, 4-difluorophenylpyridine …

Oleanolic acid dimers with potential application in medicine—Design, synthesis, physico-chemical characteristics, cytotoxic and antioxidant activity

A Günther, P Zalewski, S Sip, P Ruszkowski… - International Journal of …, 2024 - mdpi.com
The present work aimed to obtain a set of oleanolic acid derivatives with a high level of
cytotoxic and antioxidant activities and a low level of toxicity by applying an economical …

Anti-tumor effects of novel alkannin derivatives with potent selectivity on comprehensive analysis

Z Dai, F Gao, Z Zhang, M Lu, Y Luo, T Zhang, B Shang… - Phytomedicine, 2023 - Elsevier
Background Therapeutic approaches based on glycolysis and energy metabolism of tumor
cells are new promising strategies for the treatment of cancer. Currently, researches on the …

A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity

N Bayrak, H Yıldırım, M Yıldız… - Chemical Biology & …, 2020 - Wiley Online Library
Herein, we report the synthesis and cytotoxic effects of novel chlorinated plastoquinone
analogs (ABQ1–17) against different leukemic cells. Compounds ABQ3, ABQ11, and ABQ12 …

Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain

JM Calderón-Montaño, SM Martínez-Sánchez… - Plants, 2021 - mdpi.com
Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the
low survival rates of patients diagnosed with metastatic cancers. Since plants are an …

A new family of luminescent [Pt (pbt) 2 (C 6 F 5) L] n+ (n= 1, 0) complexes: synthesis, optical and cytotoxic studies

DG de Segura, N Giménez, D Rincón-Montón… - Dalton …, 2023 - pubs.rsc.org
Given the widely recognized bioactivity of 2-arylbenzothiazoles against tumor cells, we have
designed a new family of luminescent heteroleptic pentafluorophenyl-bis (2 …

Discovery and structure–activity relationship of plastoquinone analogs as anticancer agents against chronic myelogenous leukemia cells

HI Ciftci, N Bayrak, H Yıldırım, M Yıldız… - Archiv der …, 2019 - Wiley Online Library
Abstract Two series of amino‐1, 4‐benzoquinones (AQ1–18) based on the structural
analogs of plastoquinones were synthesized and the structure–activity relationship against …

Aminated Quinolinequinones as Privileged Scaffolds for Antibacterial Agents: Synthesis, In Vitro Evaluation, and Putative Mode of Action

H Yıldırım, N Bayrak, M Yıldız, E Mataracı-Kara… - ACS …, 2022 - ACS Publications
Our previous studies have revealed that the aminated 1, 4-quinone scaffold can be used for
the development of novel antibacterial and/or antifungal agents. In this study, the aminated …