We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

Hypertensive heart disease is a constellation of abnormalities that includes left ventricular
hypertrophy (LVH), systolic and diastolic dysfunction, and their clinical manifestations …

Abstract Systems genetics is an approach to understand the flow of biological information
that underlies complex traits. It uses a range of experimental and statistical methods to …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

Objectives: The goal of this study was to assess the prognostic significance of midwall and
infarct patterns of late gadolinium enhancement (LGE) in aortic stenosis. Background …

The molecular pathways that are activated and contribute to physiological remodeling of
skeletal muscle in response to endurance exercise have not been fully characterized. We …

Hypertensive heart disease constitutes functional and structural dysfunction and
pathogenesis occurring primarily in the left ventricle, the left atrium and the coronary arteries …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome …

Background Cardiovascular magnetic resonance (CMR) is the gold standard non-invasive
method for determining left ventricular (LV) mass and volume but has not been used …

Combined analyses of gene networks and DNA sequence variation can provide new
insights into the aetiology of common diseases that may not be apparent from genome-wide …