Valvular heart diseases (VHDs) are currently treated using either mechanical or
bioprosthetic heart valves. Unfortunately, mechanical valves require lifelong anticoagulation …

Calcific aortic valve disease (CAVD) is the most frequent heart valve disorder. It is
characterized by an active remodeling process accompanied with valve mineralization, that …

Heart valves are characterized to be highly flexible yet tough, and exhibit complex
deformation characteristics such as nonlinearity, anisotropy, and viscoelasticity, which are …

Tissue engineered heart valves (TEHVs) that can grow and remodel have the potential to
serve as permanent replacements of the current non-viable prosthetic valves particularly for …

Often the only treatment available for patients suffering from diseased and injured organs is
whole organ transplant. However, there is a severe shortage of donor organs for …

Tissue engineered heart valves (TEHV) can be useful in the repair of congenital or acquired
valvular diseases due to their potential for growth and remodeling. The development of …

OBJECTIVE: Mechanical and biological prostheses are used to replace damaged heart
valves but are associated with significant morbidities. Although there is increased interest in …

Microfabricated poly (glycerol sebacate)(PGS) scaffolds may be applicable to tissue
engineering heart valve leaflets by virtue of their controllable microstructure, stiffness, and …

In‐body tissue architecture—a novel and practical regeneration medicine technology—can
be used to prepare a completely autologous heart valve, based on the shape of a mold. In …

Tissue engineered replacement heart valves may be capable of overcoming the lack of
growth potential intrinsic to current non-viable prosthetics, and thus could potentially serve …