Due to the growing concerns on the climate change and sustainability on petrochemical
resources, DOE selected and announced the bio-based top 12 building blocks and …

Vitamin B 12 is an essential vitamin that is widely used in medical and food industries.
Vitamin B 12 biosynthesis is confined to few bacteria and archaea, and as such its …

Highlights•Industrially produced B vitamins are widely used in feed, food, cosmetics and
pharma.•Most B vitamins are produced by chemical synthesis in a non-sustainable …

The only known source of vitamin B12 (adenosylcobalamin) is from bacteria and archaea.
Here, using genetic and metabolic engineering, we generate an Escherichia coli strain that …

Many microbial producers of coenzyme B12 family cofactors together with their metabolically
interdependent pathways are comprehensively studied and successfully used both in …

Highlights•The use of inexpensive carbon sources is urgently needed for citric acid
production.•Low-pH process benefits lactic acid production.•Different strains and processes …

Adenosylcobalamin (AdoCbl), a biologically active form of vitamin B12 (coenzyme B12), is
one of the most complex metal-containing natural compounds and an essential vitamin for …

Utilization of abundant and cheap carbon sources can effectively reduce the production cost
and enhance the economic feasibility. Acetate is a promising carbon source to achieve cost …

The production of high added-value chemicals from renewable resources is a necessity in
our attempts to switch to a more sustainable society. 3-Hydroxypropionic acid (3HP) is a …

Hydroxypropionic acid (3-HP) represents an economically important platform compound
from which a panel of bulk chemicals can be derived. Compared with petroleum-dependent …