Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Haematopoietic stem cells self-renew and differentiate into all blood lineages throughout
life, and can repair damaged blood systems upon transplantation. Asymmetric cell division …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Aberrant proliferation, symmetric self-renewal, increased survival, and defective
differentiation of malignant blasts are key oncogenic drivers in acute myeloid leukemia …

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain
homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is …

Pancreatic intraepithelial neoplasia is a pre-malignant lesion that can progress to pancreatic
ductal adenocarcinoma, a highly lethal malignancy marked by its late stage at clinical …

Stress-induced cleavage of transfer RNAs (tRNAs) into tRNA-derived fragments (tRFs)
occurs across organisms from yeast to humans; yet, its mechanistic underpinnings and …