Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …

Closely related to studying the function of a protein is the analysis of its three‐dimensional
structure and the identification of interaction sites with its binding partners. An alternative …

The widespread applications of benzophenone (BP) photochemistry in biological chemistry,
bioorganic chemistry, and material science have been prominent in both academic and …

To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch
repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an …

Protein− protein interactions are vital for almost all cellular functions, and many require the
formation of multiprotein complexes. Identification of the macroscopic and microscopic …

MutH initiates mismatch repair by nicking the transiently unmethylated daughter strand 5′
to a GATC sequence. Here, we report crystal structures of MutH complexed with …

GHL proteins are functionally diverse enzymes defined by the presence of a conserved
ATPase domain that self-associates to trap substrate upon nucleotide binding. The structural …

The principal DNA mismatch repair proteins MutS and MutL are versatile enzymes that
couple DNA mismatch or damage recognition to other cellular processes. Besides …

MutLα, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch
repair. It interacts ATP-dependently with the mismatch detector MutSα and assembles and …