Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in
several fields of medicine to prevent or treat venous and arterial thromboembolism …

Allergic diseases are allergen‐induced immunological disorders characterized by the
development of type 2 immunity and IgE responses. The prevalence of allergic diseases has …

Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …

Background Multiple pleiotropic effects of statins include antithrombotic properties with
formation of looser fibrin networks more susceptible to lysis. Recently, rosuvastatin 20 mg/d …

Anticoagulant drugs that are currently used to prevent and/or treat thrombosis have some
limitations that hinder their ability to meet specific clinical requirements. While these drugs …

The plasma protein factor XII (FXII) is the liver-derived zymogen of the serine protease FXIIa
that initiates an array of proteolytic cascades. Zymogen activation, enzymatic FXIIa activity …

Direct Oral Anticoagulants (DOACs) have simplified the treatment of thromboembolic
disease. In addition to their established anticoagulant effects, there are indications from …

Unique among coagulation factors, the coagulation factor XI (FXI) arose through a
duplication of the gene KLKB1, which encodes plasma prekallikrein. This evolutionary origin …

Anticoagulants are the mainstay for the prevention and treatment of thrombosis. However,
bleeding complications remain a primary concern. Recent advances in understanding the …

Multiple sclerosis (MS) is the most common causes of non-traumatic disability in young
adults worldwide. MS pathophysiologies include the formation of inflammatory lesions …