There is considerable evidence that the antioxidant activity of high density lipoprotein (HDL)
is largely due to the paraoxonase-1 (PON1) located on it. Experiments with transgenic PON1 …

This review focuses on the functional genomics of the human paraoxonase (PON1)
polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) …

Human serum paraoxonase (PON1) hydrolyzes oxidized lipids in low density lipoprotein
(LDL) and could therefore retard the development of atherosclerosis. In keeping with this …

Background Although there have been suggestions that serum paraoxonase is important in
protecting against coronary heart disease (CHD), a large number of studies of genetic …

The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been
inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary …

Human serum paraoxonase (PON1) is an esterase that is bound to high-density lipoproteins
(HDLs). It can hydrolyze organophosphates and its activity is inversely related to …

Objective—The effects of paraoxonase (PON1) activity and of genetic variation in the PON1
promoter and coding region on carotid artery disease (CAAD) were investigated. Methods …

Abstract Background: Paraoxonase 1 (PON1) phenotype is a better predictor of
atherosclerosis risk than are PON1 genetic polymorphisms alone. Larger studies are …

OBJECTIVE: The human paraoxonase (PON) is calcium dependent HDL associated ester
hydrolase which has attracted considerable attention as a candidate gene for coronary heart …

The one disease associated with the greatest morbidity and mortality in industrialized
countries is coronary heart disease (CHD). High density lipoprotein (HDL) is one of the most …