[HTML][HTML] The clinical impact of the molecular landscape of acute myeloid leukemia
S Kayser, MJ Levis - Haematologica, 2023 - ncbi.nlm.nih.gov
Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …
led to remarkable advances in our understanding of the disease. Mutations now allow us to …
Contemporary Approach to Acute Myeloid Leukemia Therapy in 2022.
Recent advances in acute myeloid leukemia biology and drug development have
transformed the therapeutic landscape for patients diagnosed with this disease. By …
transformed the therapeutic landscape for patients diagnosed with this disease. By …
[PDF][PDF] Impact of Venetoclax and Azacitidine in Treatment-Naïve Patients with Acute Myeloid Leukemia and IDH1/2 Mutations
DA Pollyea, CD DiNardo, ML Arellano, A Pigneux… - Clinical Cancer …, 2022 - AACR
Purpose: To evaluate efficacy and safety of venetoclax+ azacitidine among treatment-naïve
patients with IDH1/2-mutant (mut) acute myeloid leukemia (AML). Patients and Methods …
patients with IDH1/2-mutant (mut) acute myeloid leukemia (AML). Patients and Methods …
AVALON: The Italian cohort study on real‐life efficacy of hypomethylating agents plus venetoclax in newly diagnosed or relapsed/refractory patients with acute myeloid …
E Todisco, C Papayannidis, N Fracchiolla, E Petracci… - Cancer, 2023 - Wiley Online Library
Background Venetoclax in combination with hypomethylating agents (HMA) is
revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large …
revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large …
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis
S Zarnegar-Lumley, TA Alonzo, RB Gerbing… - Blood …, 2023 - ashpublications.org
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute
myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study …
myeloid leukemia (AML) and less commonly in pediatric AML. The objective of this study …
IDH Mutations in Chondrosarcoma: Case Closed or Not?
S Venneker, JVMG Bovée - Cancers, 2023 - mdpi.com
Simple Summary Chondrosarcomas are cartilage tumours that often harbour a mutation in
one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the …
one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the …
Differential impact of IDH1/2 mutational subclasses on outcome in adult AML: results from a large multicenter study
Mutations of the isocitrate dehydrogenase-1 (IDH1) and IDH2 genes are among the most
frequent alterations in acute myeloid leukemia (AML) and can be found in∼ 20% of patients …
frequent alterations in acute myeloid leukemia (AML) and can be found in∼ 20% of patients …
Recent advances of IDH1 mutant inhibitor in cancer therapy
W Tian, W Zhang, Y Wang, R Jin, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of
isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in …
isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in …
Modern risk stratification of acute myeloid leukemia in 2023: integrating established and emerging prognostic factors
E Boscaro, I Urbino, FM Catania, G Arrigo, C Secreto… - Cancers, 2023 - mdpi.com
Simple Summary Several factors, both patient-and disease-related, are essential to
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …
accurately estimate acute myeloid leukemia (AML) prognosis. The rapidly evolving field …
Comprehensive analysis of ferroptosis-related gene signatures as a potential therapeutic target for acute myeloid leukemia: A bioinformatics analysis and …
Z Zheng, X Hong, X Huang, X Jiang, H Jiang… - Frontiers in …, 2022 - frontiersin.org
Background Ferroptosis plays an important role in the development of acute myeloid
leukemia (AML); however, the exact role of ferroptosis-related genes in the prognosis of …
leukemia (AML); however, the exact role of ferroptosis-related genes in the prognosis of …