The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

Cytotoxic T cells and natural killer cells are crucial for immune surveillance against virus-
infected cells and tumour cells. Molecular studies of individuals with inherited defects that …

▪ Abstract Clathrin was discovered nearly 25 years ago. Since then, a large number of other
proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic …

Hermansky-Pudlak syndrome (HPS) is a genetic disorder characterized by defective
lysosome-related organelles. Here, we report the identification of two HPS patients with …

West Nile virus (WNV), and related flaviviruses such as tick-borne encephalitis, Japanese
encephalitis, yellow fever and dengue viruses, constitute a significant global human health …

▪ Abstract Clathrin-coated vesicles (CCVs) are responsible for the transport of proteins
between various compartments of the secretory and endocytic systems. Clathrin forms a …

Lysosomes are membrane‐bound cytoplasmic organelles involved in intracellular protein
degradation. They contain an assortment of soluble acid‐dependent hydrolases and a set of …