Is adynamic bone always a disease? Lessons from patients with chronic kidney disease

E Nagy, MM Sobh, M Abdalbary, S Elnagar… - Journal of Clinical …, 2022 - mdpi.com
Renal osteodystrophy (ROD) is a common complication of end-stage kidney disease that
often starts early with loss of kidney function, and it is considered an integral part in …

Protein-bound uremic toxins in senescence and kidney fibrosis

Y Yang, M Mihajlovic, R Masereeuw - Biomedicines, 2023 - mdpi.com
Chronic kidney disease (CKD) is a progressive condition of kidney dysfunction due to
diverse causes of injury. In healthy kidneys, protein-bound uremic toxins (PBUTs) are …

Ibuprofen-Immobilized Thin Films: A Novel Approach to Improve the Clearance of Protein-Bound Uremic Toxins

FSC Rodrigues, D Brilhante, A Macêdo… - … Applied Materials & …, 2024 - ACS Publications
Chronic kidney disease (CKD), a pressing global health issue, affects millions and leads to
end-stage renal disease (ESRD). Hemodialysis (HD) is a crucial treatment for ESRD, yet its …

Interaction of human serum albumin with uremic toxins: the need of new strategies aiming at uremic toxins removal

F Zare, A Janeca, SM Jokar, M Faria, MC Gonçalves - Membranes, 2022 - mdpi.com
Chronic kidney disease (CKD) is acknowledged worldwide to be a grave threat to public
health, with the number of US end-stage kidney disease (ESKD) patients increasing steeply …

Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach

R Asadi, P Shadpour, A Nakhaei - European journal of medical research, 2024 - Springer
Background Chronic kidney disease presents global health challenges, with hemodialysis
as a common treatment. However, non-dialyzable uremic toxins demand further …

Recent Advances and Future Perspectives in the Use of Machine Learning and Mathematical Models in Nephrology

PP Galuzio, A Cherif - Advances in Chronic Kidney Disease, 2022 - Elsevier
We reviewed some of the latest advancements in the use of mathematical models in
nephrology. We looked over 2 distinct categories of mathematical models that are widely …

Future research perspectives in hemodialysis membrane technology

M Iftikhar, MHD Othman, IU Khan, NJ Ismail… - Journal of Industrial and …, 2024 - Elsevier
Hemodialysis is the prevailing approach in renal replacement therapy, critically required for
eliminating uremic toxins from the blood of individuals suffering from end-stage renal …

Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review

S Ahmed, JC de Vries, J Lu, MHV Stuart… - International Journal of …, 2023 - mdpi.com
Protein-bound uremic toxins (PBUTs) are associated with the progression of chronic kidney
disease (CKD) and its associated morbidity and mortality. The conventional dialysis …

A Novel Strategy for Enhanced Sequestration of Protein-Bound Uremic Toxins Using Smart Hybrid Membranes

M Lopes, RF Pires, M Faria, VDB Bonifácio - Journal of Functional …, 2023 - mdpi.com
Currently available hemodialysis (HD) membranes are unable to safely remove protein-
bound uremic toxins (PBUTs), especially those bonded to human serum albumin (HSA). To …

Displacing the Burden: A Review of Protein-Bound Uremic Toxin Clearance Strategies in Chronic Kidney Disease

D Sánchez-Ospina, S Mas-Fontao… - Journal of Clinical …, 2024 - mdpi.com
Uremic toxins (UTs), particularly protein-bound uremic toxins (PBUTs), accumulate in
chronic kidney disease (CKD) patients, causing significant health complications like uremic …