Next-generation sequencing technology: current trends and advancements
H Satam, K Joshi, U Mangrolia, S Waghoo, G Zaidi… - Biology, 2023 - mdpi.com
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics
research. NGS can sequence millions of DNA fragments at once, providing detailed …
research. NGS can sequence millions of DNA fragments at once, providing detailed …
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
TH Beacon, GP Delcuve, C López, G Nardocci… - Clinical …, 2021 - Springer
Transcriptionally active chromatin is marked by tri-methylation of histone H3 at lysine 4
(H3K4me3) located after first exons and around transcription start sites. This epigenetic mark …
(H3K4me3) located after first exons and around transcription start sites. This epigenetic mark …
The ENCODE blacklist: identification of problematic regions of the genome
Functional genomics assays based on high-throughput sequencing greatly expand our
ability to understand the genome. Here, we define the ENCODE blacklist-a comprehensive …
ability to understand the genome. Here, we define the ENCODE blacklist-a comprehensive …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
Cistrome and epicistrome features shape the regulatory DNA landscape
The cistrome is the complete set of transcription factor (TF) binding sites (cis-elements) in an
organism, while an epicistrome incorporates tissue-specific DNA chemical modifications and …
organism, while an epicistrome incorporates tissue-specific DNA chemical modifications and …
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …
Mapping genome-wide transcription-factor binding sites using DAP-seq
To enable low-cost, high-throughput generation of cistrome and epicistrome maps for any
organism, we developed DNA affinity purification sequencing (DAP-seq), a transcription …
organism, we developed DNA affinity purification sequencing (DAP-seq), a transcription …
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
[HTML][HTML] Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas
High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of
H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping …
H3K27 trimethylation and reciprocal gain of H3K27 acetylation, respectively shaping …