Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …

Models of electrical activation and recovery in cardiac cells and tissue have become
valuable research tools, and are beginning to be used in safety-critical applications …

Background: Pulmonary vein isolation (PVI) is an effective treatment strategy for patients
with atrial fibrillation (AF), but many experience AF recurrence and require repeat ablation …

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies
on the numerical approximation of coupled nonlinear dynamical systems. These systems …

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant
drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy …

Clinical evidence suggests a link between fibrosis in the left atrium (LA) and atrial fibrillation
(AF), the most common sustained arrhythmia. Image-derived fibrosis is increasingly used for …

Atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia in clinical
practice. However, current therapeutic interventions for atrial fibrillation have limited clinical …

Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by
alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo …

Fractional differential equations have become a fundamental modelling approach for
understanding and simulating the many aspects of non-locality and spatial heterogeneity of …

We previously reported the feasibility and efficacy of a simulation-guided clinical catheter
ablation of atrial fibrillation (AF) in an in-silico AF model. We developed a highly efficient …