The use of proteins as therapeutics has a long history and is becoming ever more common
in modern medicine. While the number of protein-based drugs is growing every year …

The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS)
from damage by substances that originate from the blood circulation. The BBB limits drug …

Multilayered polymer particles with a wide range of properties can be precisely engineered
via the layer-by-layer technique using a multitude of templates and materials. Such …

Over the past few decades, nanoengineered particles have gained increasing interest for
applications in the biomedical realm, including diagnosis, imaging, and therapy. When …

Hollow polymer capsules are attracting increasing research interest due to their potential
application as drug delivery vectors, sensors, biomimetic nano-or multi-compartment …

Targeted nanomedicines have significantly changed the way new therapeutics are designed
to treat disease. Central to successful therapeutics is the ability to control the dynamics of …

Sortase‐mediated hydrazinolysis of proteins with hydrazine or its derivatives was developed
for the production of recombinant protein hydrazides. This process provides an alternative …

Conspectus Nanoengineered materials offer tremendous promise for developing the next
generation of therapeutics. We are transitioning from simple research questions, such as …

Engineered particles adsorb biomolecules (eg, proteins) when introduced in a biological
medium to form a layer called a “corona”. Coronas, in particular the protein corona, play an …

Sortase‐mediated ligation (SML) has emerged as a powerful and versatile methodology for
site‐specific protein conjugation, functionalization/labeling, immobilization, and design of …