Transient receptor potential canonical (TRPC) channels constitute a group of receptor-
operated calcium-permeable nonselective cation channels of the TRP superfamily. The …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

The last 20–25 years have seen an explosion of interest in the role of NADPH oxidase
(NOX) in cardiovascular function and disease. In vascular smooth muscle and endothelium …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

Pulmonary arterial hypertension (PAH) is a multifactorial and severe disease without
curative therapies. PAH pathobiology involves altered pulmonary arterial tone, endothelial …

Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+
influx in non-excitable and excitable (ie, skeletal and cardiac muscle) cells. These channels …

It is now widely accepted that advanced fibrosis underlies many chronic inflammatory
disorders and is the main cause of morbidity and mortality of the modern world. The …

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure.
The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a …

Abstract Calcium (Ca 2+) is a universal signaling ion, whose major informational role
shaped the evolution of signaling pathways, enabling cellular communications and …

Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …