Neuro-inflammation modulation and post-traumatic brain injury lesions: from bench to bed-side

A Jacquens, EJ Needham, ER Zanier, V Degos… - International journal of …, 2022 - mdpi.com
Head trauma is the most common cause of disability in young adults. Known as a silent
epidemic, it can cause a mosaic of symptoms, whether neurological (sensory–motor …

Treating traumatic brain injury with minocycline

PJ Bergold, R Furhang, S Lawless - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed,
complexity, and persistence of TBI present large obstacles to drug development. Preclinical …

[HTML][HTML] Healthy human fecal microbiota transplantation into mice attenuates MPTP-induced neurotoxicity via AMPK/SOD2 pathway

Z Xie, M Zhang, Y Luo, D Jin, X Guo, W Yang… - Aging and …, 2023 - ncbi.nlm.nih.gov
Increasing evidence has shown that gut dysbacteriosis may play a crucial role in
neuroinflammation in Parkinson's disease (PD). However, the specific mechanisms that link …

Human Glial Cells as Innovative Targets for the Therapy of Central Nervous System Pathologies

G Magni, B Riboldi, S Ceruti - Cells, 2024 - mdpi.com
In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial
physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and …

Myricetin suppresses traumatic brain injury-induced inflammatory response via EGFR/AKT/STAT pathway

C Wang, S Ouyang, X Zhu, Y Jiang, Z Lu, P Gong - Scientific Reports, 2023 - nature.com
Traumatic brain injury (TBI) is a common disease in neurosurgery with a high fatality and
disability rate which imposes a huge burden on society and patient's family. Inhibition of …

Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models

K Ritter, P Somnuke, L Hu, EV Griemert… - BMC neuroscience, 2024 - Springer
TBI is a leading cause of death and disability in young people and older adults worldwide.
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …

Acute exposure of microwave impairs attention process by activating microglial inflammation

S Jiang, Y Ma, Y Shi, Y Zou, Z Yang, W Zhi, Z Zhao… - Cell & Bioscience, 2024 - Springer
Background Attention provides the foundation for cognitions, which was shown to be
affected by microwave (MW) radiation. With the ubiquitous of microwaves, public concerns …

P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder

S Bou Sader Nehme, S Sanchez-Sarasua… - Frontiers in …, 2024 - frontiersin.org
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common
neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsivity that …

Testing the efficacy of minocycline treatment in an awake, female rat model of repetitive mild head injury

R Hightower, E Brengel, S Prom, P Kulkarni, C Ferris - 2024 - researchsquare.com
Minocycline is being tested in clinical trials for the treatment of stroke. As an antibiotic it
reduces microglia activation. Can minocycline be used to treat mild head injury? To that end …

A Mixed Methods Examination of the Impact of Clark v. Arizona

JA Purdon - 2023 - search.proquest.com
Abstract The United States Supreme Court decision in Clark v. Arizona has become a
fundamental part of the landscape concerning the insanity defense and, as a result, has …