[HTML][HTML] Molecular properties and regulation of NAD+ kinase (NADK)
S Oka, AS Titus, D Zablocki, J Sadoshima - Redox Biology, 2023 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby
producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and …
producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and …
NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease
WM Curtis, WA Seeds, MP Mattson, PC Bradshaw - Cells, 2022 - mdpi.com
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
[HTML][HTML] The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity
LE Jamerson, PC Bradshaw - Antioxidants, 2024 - mdpi.com
Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of
fasting, meal consumption increases lipogenic gene expression, including that of NADPH …
fasting, meal consumption increases lipogenic gene expression, including that of NADPH …
[HTML][HTML] Mitochondrial NAD kinase in health and disease
R Zhang, K Zhang - Redox Biology, 2023 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron
carrier, plays crucial roles in numerous biological functions, including cellular metabolism …
carrier, plays crucial roles in numerous biological functions, including cellular metabolism …
Staphylococcal exoribonuclease YhaM destabilizes ribosomes by targeting the mRNA of a hibernation factor
The hibernation-promoting factor (Hpf) in Staphylococcus aureus binds to 70S ribosomes
and induces the formation of the 100S complex (70S dimer), leading to translational …
and induces the formation of the 100S complex (70S dimer), leading to translational …
Metabolic control of collagen synthesis
J Guillard, S Schwörer - Matrix Biology, 2024 - Elsevier
The extracellular matrix (ECM) is present in all tissues and crucial in maintaining normal
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …
tissue homeostasis and function. Defects in ECM synthesis and remodeling can lead to …
De novo and salvage purine synthesis pathways across tissues and tumors
Purine nucleotides are vital for RNA and DNA synthesis, signaling, metabolism, and energy
homeostasis. To synthesize purines, cells use two principal routes: the de novo and salvage …
homeostasis. To synthesize purines, cells use two principal routes: the de novo and salvage …
Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria
DA Clément, M Gelin, C Leseigneur, V Huteau… - European Journal of …, 2023 - Elsevier
Nicotinamide adenine dinucleotide kinases (NAD kinases) are essential and ubiquitous
enzymes involved in the production of NADP (H) which is an essential cofactor in many …
enzymes involved in the production of NADP (H) which is an essential cofactor in many …
Homeostatic regulation of NAD (H) and NADP (H) in cells
Abstract Nicotinamide adenine dinucleotide (NAD+)/reduced NAD+(NADH) and
nicotinamide adenine dinucleotide phosphate (NADP+)/reduced NADP+(NADPH) are …
nicotinamide adenine dinucleotide phosphate (NADP+)/reduced NADP+(NADPH) are …
Structure‐based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase
R Rahimova, P Nogaret, V Huteau, M Gelin… - The FEBS …, 2023 - Wiley Online Library
Multidrug resistance is a major public health problem that requires the urgent development
of new antibiotics and therefore the identification of novel bacterial targets. The activity of …
of new antibiotics and therefore the identification of novel bacterial targets. The activity of …