Apicomplexan parasites, including the Plasmodium species that cause malaria, contain
three unusual apical secretory organelles (micronemes, rhoptries, and dense granules) that …

Rhoptries are club-shaped secretory organelles located at the anterior pole of species
belonging to the phylum of Apicomplexa. Parasites of this phylum are responsible for a huge …

The malaria genome encodes over 5,000 proteins and many of these have also been
proposed to be potential vaccine candidates, although few of these have been tested …

Host cell infection by apicomplexan parasites plays an essential role in lifecycle progression
for these obligate intracellular pathogens. For most species, including the etiological agents …

In the Plasmodium lifecycle two infectious stages of parasites, merozoites, and sporozoites,
efficiently infect mammalian host cells, erythrocytes, and hepatocytes, respectively. The …

Red blood cell (RBC) invasion and parasitophorous vacuole (PV) formation by Plasmodium
falciparum are critical for the development and pathogenesis of malaria, a continuing global …

Carbonic anhydrase-related proteins (CARPs) have previously been described as
catalytically inactive proteins closely related to α-carbonic anhydrases (α-CAs). These …

Apicomplexan parasites secrete and inject into the host cell the content of specialized
secretory organelles called rhoptries, which take part into critical processes such as host cell …

Given the lack of knowledge on the rhoptry proteins of Cryptosporidium parvum, we
searched for putative members of this protein class in the CryptoDB database using as …

Background Plasmodium vivax malaria remains a major health problem in tropical and sub-
tropical regions worldwide. Several rhoptry proteins which are important for interaction with …