Technological and computational advances driving high-throughput oncology

L Kolmar, A Autour, X Ma, B Vergier, F Eduati… - Trends in Cell …, 2022 - cell.com
Engineering and computational advances have opened many new avenues in cancer
research, particularly when being exploited in interdisciplinary approaches. For example …

Application of microfluidic systems for breast cancer research

ZD Frankman, L Jiang, JA Schroeder, Y Zohar - Micromachines, 2022 - mdpi.com
Cancer is a disease in which cells in the body grow out of control; breast cancer is the most
common cancer in women in the United States. Due to early screening and advancements …

Development of Nano–Micro Fused LSPR Chip for In Situ Single-Cell Secretion Analysis

Y Terada, A Obara, JC Briones, X Luo, WV Espulgar… - Micromachines, 2023 - mdpi.com
Single-cell analysis has become increasingly important in uncovering cell heterogeneity,
which has great implications in medicine and biology for a deep understanding of cell …

Linking antigen specific T-cell dynamics in a microfluidic chip to single cell transcription patterns

H Ide, T Aoshi, M Saito, WV Espulgar… - Biochemical and …, 2023 - Elsevier
A new non-invasive screening profile has been realized that can aid in determining T-cell
activation state at single-cell level. Production of activated T-cells with good specificity and …

Microfluidic devices as process development tools for cellular therapy manufacturing

J Aranda Hernandez, C Heuer, J Bahnemann… - Microfluidics in …, 2021 - Springer
Cellular therapies are creating a paradigm shift in the biomanufacturing industry. Particularly
for autologous therapies, small-scale processing methods are better suited than the large …

Microfluidic device combining hydrodynamic and dielectrophoretic trapping for the controlled contact between single micro-sized objects and application to adhesion …

C Lipp, L Koebel, R Loyon, A Bolopion, L Spehner… - Lab on a Chip, 2023 - pubs.rsc.org
The understanding of cell–cell and cell–matrix interactions via receptor and ligand binding
relies on our ability to study the very first events of their contact. Of particular interest is the …

Recapitulating the Cancer‐Immunity Cycle on a Chip

Y Lee, J Min, S Kim, W Park, J Ko… - Advanced Healthcare … - Wiley Online Library
The cancer‐immunity cycle is a fundamental framework for understanding how the immune
system interacts with cancer cells, balancing T cell recognition and elimination of tumors …