Estrogen and progesterone and their signaling mechanisms are tightly regulated to maintain
a normal menstrual cycle and to support a successful pregnancy. The imbalance of estrogen …

BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial
tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the …

Adenomyosis is a common disorder of the uterus, and is associated with an enlarged uterus,
heavy menstrual bleeding (HMB), pelvic pain, and infertility. It is characterized by …

Endometriosis and adenomyosis are closely related disorders. Their pathophysiologies are
extremely similar. Both tissues originate from the eutopically located intracavitary …

The aim of this review article was to summarize our current understanding on the etiologies
and pathogenesis of human adenomyosis and to clarify the relative association between …

In brief Traditionally viewed as enigmatic and elusive, adenomyosis is a fairly common
gynecological disease but is under-recognized and under-researched. This review …

It has become evident that somatic mutations in cancer-associated genes accumulate in the
normal endometrium, but spatiotemporal understanding of the evolution and expansion of …

According to consistent epidemiological data, the slope of the incidence curve of
endometriosis rises rapidly and sharply around the age of 25 years. The delay in diagnosis …

Uterine adenomyosis is a common chronic disorder frequently encountered in reproductive-
age women, causing heavy menstrual bleeding, intense pelvic pain, and infertility. Despite …

Uterine adenomyosis is a benign disease, commonly encountered in reproductive-age
women and responsible for chronic pelvic pain, abnormal uterine bleeding, and infertility …