[HTML][HTML] Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

The stomach in health and disease

RH Hunt, M Camilleri, SE Crowe, EM El-Omar, JG Fox… - Gut, 2015 - gut.bmj.com
The stomach is traditionally regarded as a hollow muscular sac that initiates the second
phase of digestion. Yet this simple view ignores the fact that it is the most sophisticated …

[图书][B] Understanding nutrition

EN Whitney, SR Rolfes, T Crowe, A Walsh - 2019 - books.google.com
Building upon Ellie Whitney and Sharon Rady Rolfes' classic text, this fourth Australian and
New Zealand edition of Understanding Nutrition is a practical and engaging introduction to …

Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism

Y Lv, T Liang, G Wang, Z Li - Bioscience reports, 2018 - portlandpress.com
Ghrelin, an acylated peptide hormone of 28 amino acids, is an endogenous ligand of the
released growth hormone secretagogue receptor (GHSR). Ghrelin has been isolated from …

The regulation of food intake by the gut-brain axis: implications for obesity

SS Hussain, SR Bloom - International journal of obesity, 2013 - nature.com
Our understanding of the regulation of appetite has improved considerably over the last few
decades. Recent work, stimulated by efforts aimed at curbing the current obesity epidemic …

Ghrelin signalling and obesity: at the interface of stress, mood and food reward

H Schellekens, BC Finger, TG Dinan… - Pharmacology & …, 2012 - Elsevier
The neuronal circuitry underlying the complex relationship between stress, mood and food
intake are slowly being unravelled and several studies suggest a key role herein for the …

Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric bypass

C Dirksen, NB Jørgensen, KN Bojsen-Møller… - International journal of …, 2013 - nature.com
Objective: To identify factors contributing to the variation in weight loss after Roux-en-Y
gastric bypass (RYGB). Design: Cross-sectional study of patients with good (excess body …

[HTML][HTML] Analysis of energy metabolism in humans: A review of methodologies

YY Lam, E Ravussin - Molecular metabolism, 2016 - Elsevier
Background Obesity is a consequence of chronic energy imbalance. We need accurate and
precise measurements of energy intake and expenditure, as well as the related behaviors, to …

Placental regulation of energy homeostasis during human pregnancy

B Armistead, E Johnson, R VanderKamp… - …, 2020 - academic.oup.com
Successful pregnancies rely on sufficient energy and nutrient supply, which require the
mother to metabolically adapt to support fetal needs. The placenta has a critical role in this …

Ghrelin's orexigenic effect is modulated via a serotonin 2C receptor interaction

H Schellekens, PN De Francesco… - ACS chemical …, 2015 - ACS Publications
Understanding the intricate pathways that modulate appetite and subsequent food intake is
of particular importance considering the rise in the incidence of obesity across the globe …