Depending on their primary structure, the 28 mammalian transient receptor potential (TRP)
cation channels identified so far can be sorted into 6 subfamilies: TRPC (“Canonical”), TRPV …

The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly
expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain …

The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel
expressed by peripheral sensory neurons. TRPV1 antagonists produce antihyperalgesic …

The adequate stimuli and molecular receptors for muscle metaboreceptors and nociceptors
are still under investigation. We used calcium imaging of cultured primary sensory dorsal …

Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory
neurons triggering an influx of cations. TRPV1 receptors function as homotetramers …

The exquisite specific excitatory and desensitising actions of capsaicin on a subpopulation
of primary sensory neurons have been instrumental in identifying the roles of these neurons …

Injury or inflammation release a range of inflammatory mediators that increase the sensitivity
of sensory neurons to noxious thermal or mechanical stimuli. The heat-and capsaicin-gated …

The capsaicin receptor TRPV1 is an emerging target for the treatment of pain with a unique
expression profile in peripheral nociceptors and the ability to show polymodal activation …

The transient receptor potential vanilloid 1 (TRPV1) is an excitatory cation channel, rather
selectively expressed in a subpopulation of nociceptive, primary sensory neurons that …

Capsaicin, the pungent ingredient in red pepper, has been used since ancient times as a
spice, despite the burning sensation associated with its intake. More than 50 years ago …