Modern health care has brought our society innumerable benefits but has also introduced
the experience of pain very early in life. For example, it is now routine care for newborns to …

Recommendations for postoperative pain in children continue to evolve, with data
incorporated from randomized controlled trials, case series and large audits. Management of …

Neonatal hindpaw incision primes developing spinal nociceptive circuitry, resulting in
enhanced hyperalgesia following reinjury in adulthood. Spinal microglia contribute to this …

Highlights•Early life pain induces long-term changes in response to pain, anxiety, and
stress.•Injury-induced changes in pain, anxiety and stress are due to increased opioid …

It has become clear that tissue damage during a critical period of early life can result in long-
term changes in pain sensitivity, but the underlying mechanisms remain to be fully …

The descending pain modulatory system (DPMS) constitutes a network of widely distributed
brain regions whose integrated function is essential for effective modulation of sensory input …

Pain is a necessary sensation that prevents further tissue damage, but can be debilitating
and detrimental in daily life under chronic conditions. Neuronal activity strongly regulates the …

A comprehensive assessment of pain extends beyond measuring the intensity of pain to
also include: site and radiation of pain; onset, aggravating and relieving factors; character of …

Early life pain (ELP) experience alters adult pain behavior and increases injury-induced
pain hypersensitivity, but the effect of ELP on adult functional brain connectivity is not known …

Noxious stimulation at critical stages of development has long-term consequences on
somatosensory processing in later life, but it is not known whether this developmental …