Melatonin, the main secretory product of the pineal gland, is known to collaborate against
oxidative stress within cells, but its mechanism of action in terms of stimulating antioxidant …

Gastrointestinal cancer is a disease that affects the population worldwide with high morbidity
and mortality. Melatonin, an endogenously produced molecule, may provide a defense …

Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin
increases ischemic heart disease risk. The nuclear melatonin receptors ROR s are pivotally …

An important pathophysiological component of Parkinson's Disease (PD) is circadian rhythm
disorder, closely related to a decrease in circulated melatonin (MLT) level. It has been …

The aim of the present study was to determine the existence of melatonin membrane
receptors and to examine the mRNA expression of nuclear orphan receptors in human …

Sodium nitroprusside (SNP) is an antihypertensive drug with proven dose-dependent toxic
effects attributed mainly to the production of cyanide but also excesive nitric oxide (NO) and …

Many exogenous (eg, toxins, chemicals, ultraviolet, cigarette smoke) and endogenous (eg,
hyperglycemia, dyslipidemia, cytokines, chemokines) agents disrupt the intracellular …

Like the whole organism, skin follows the process of aging during life-time. Additional to
internal factors, several environmental factors, such as solar radiation, considerably …

Melatonin has long been known for its apparent effects on sleep and circadian rhythm. It
may participate as a possible therapeutic agent in neurodegenerative, cardiovascular, and …

Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity
and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported …