The role of pain modulation pathway and related brain regions in pain

D Yao, Y Chen, G Chen - Reviews in the Neurosciences, 2023 - degruyter.com
Pain is a multifaceted process that encompasses unpleasant sensory and emotional
experiences. The essence of the pain process is aversion, or perceived negative emotion …

Pain management in pediatric burns: a review of the science behind it

B Ciornei, VL David, D Popescu, ES Boia… - Global Health …, 2023 - cambridge.org
Pediatric burns are a significant medical issue that can have long-term effects on various
aspects of a child's health and well-being. Pain management in pediatric burns is a crucial …

Gray matter volume and pain tolerance in a general population: the Tromsø study

TA Melum, TR Vangberg, LH Johnsen… - Pain, 2023 - journals.lww.com
As pain is processed by an extensive network of brain regions, the structural status of the
brain may affect pain perception. We aimed to study the association between gray matter …

Resting-state functional heterogeneity of the right insula contributes to pain sensitivity

D Veréb, B Kincses, T Spisák, F Schlitt, N Szabó… - Scientific Reports, 2021 - nature.com
Previous studies have described the structure and function of the insular cortex in terms of
spatially continuous gradients. Here we assess how spatial features of insular resting state …

Brain morphology predicts individual sensitivity to pain: a multicenter machine learning approach

R Kotikalapudi, B Kincses, M Zunhammer, F Schlitt… - Pain, 2023 - journals.lww.com
Sensitivity to pain shows a remarkable interindividual variance that has been reported to
both forecast and accompany various clinical pain conditions. Although pain thresholds …

Interindividual variability in cold-pressor pain sensitivity is not explained by peripheral vascular responding and generalizes to a C-nociceptor–specific pain phenotype

RD Martel, G Papafragou, S Weigand, R Rolke… - Pain, 2024 - journals.lww.com
Pain sensitivity of healthy subjects in the cold-pressor (CP) test was proposed to be
dichotomously distributed and to represent a pain sensitivity trait. Still, it has not been …

Temporal grading index of functional network topology predicts pain perception of patients with chronic back pain

Z Li, L Zhao, J Ji, B Ma, Z Zhao, M Wu, W Zheng… - Frontiers in …, 2022 - frontiersin.org
Chronic back pain (CBP) is a maladaptive health problem affecting the brain function and
behavior of the patient. Accumulating evidence has shown that CBP may alter the …

Prediction of individual trigeminal pain sensitivity from gray matter structure within the sensorimotor network

DM Niddam, YT Wu, LLH Pan… - … : The Journal of Head …, 2023 - Wiley Online Library
Objective To determine whether multivariate pattern regression analysis based on gray
matter (GM) images constrained to the sensorimotor network could accurately predict …

Top-down circuitry from the anterior insular cortex to VTA dopamine neurons modulates reward-related memory

E Hernandez-Ortiz, J Luis-Islas, F Tecuapetla… - Cell Reports, 2023 - cell.com
The insular cortex (IC) has been linked to the processing of interoceptive and exteroceptive
signals associated with addictive behavior. However, whether the IC modulates the …

Significant structural alterations and functional connectivity alterations of cerebellar gray matter in patients with somatic symptom disorder

HB Liang, L Dong, Y Cui, J Wu, W Tang… - Frontiers in …, 2022 - frontiersin.org
Objective Recent studies have revealed a strong association between the cerebellum and
psychiatric disorders. However, the structural changes in the cerebellar regions and …