Lipid metabolism reprogramming is an important hallmark of tumor progression. Cancer
cells require high levels of lipid synthesis and uptake not only to support their continued …

Microglia, the central nervous system innate immune cells, play a critical role in maintaining
a homeostatic environment in the brain throughout life. These cells exhibit an impressive …

Metabolic reprogramming is key for cancer development, yet the mechanism that sustains
triple-negative breast cancer (TNBC) cell growth despite deficient pyruvate kinase M2 …

Many human diseases are caused by mutations in nuclear envelope (NE) proteins. How
protein homeostasis and disease etiology are interconnected at the NE is poorly …

Cancer cells subvert multiple properties of normal cells, including escaping strict cell cycle
regulation, gaining resistance to cell death, and remodeling the tumor microenvironment …

Ethnopharmacological relevance Cinobufacini injection, an aqueous extract of the toad, is a
commonly used anti-tumor animal herbal medicine in clinical practice. It has the effects of …

As the global prototypical zoonotic hantavirus, Hantaan virus (HTNV) is prevalent in Asia
and is the leading causative agent of severe hemorrhagic fever with renal syndrome …

Background Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide,
with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor gene …

Pyruvate Kinase M2, a key enzyme in glycolysis, has garnered significant attention in cancer
research due to its pivotal role in the metabolic reprogramming of cancer cells. Originally …

Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be
fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) …