The healthy human virome: from virus–host symbiosis to disease

EV Koonin, VV Dolja, M Krupovic - Current opinion in virology, 2021 - Elsevier
Viruses are ubiquitous, essential components of any ecosystem, and of multicellular
organism holobionts. Numerous viruses cause acute infection, killing the host or being …

Why the HIV reservoir never runs dry: clonal expansion and the characteristics of HIV-infected cells challenge strategies to cure and control HIV infection

CY Lau, MA Adan, F Maldarelli - Viruses, 2021 - mdpi.com
Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Activation of endogenous retrovirus triggers microglial immuno-inflammation and contributes to negative emotional behaviors in mice with chronic stress

H Bao, J Yan, J Huang, W Deng, C Zhang, C Liu… - Journal of …, 2023 - Springer
Background The “missing” link of complex and multifaceted interplay among endogenous
retroviruses (ERVs) transcription, chronic immuno-inflammation, and the development of …

An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development

CW Lin, J Ellegood, K Tamada, I Miura, M Konda… - Molecular …, 2023 - nature.com
Abstract The BTBR T+ Itpr3 tf/J (BTBR/J) strain is one of the most valid models of idiopathic
autism, serving as a potent forward genetics tool to dissect the complexity of autism. We …

GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle

L Tang, B Swedlund, S Dupont, C Harland… - Nature …, 2024 - nature.com
Five to ten percent of mammalian genomes is occupied by multiple clades of endogenous
retroviruses (ERVs), that may count thousands of members. New ERV clades arise by …

Modulation of HERV expression by four different encephalitic arboviruses during infection of human primary astrocytes

FL Castro, OJB Brustolini, VEV Geddes, JPBM Souza… - Viruses, 2022 - mdpi.com
Human retroelements (HERVs) are retroviral origin sequences fixed in the human genome.
HERVs induction is associated with neurogenesis, cellular development, immune activation …

Regulation of endogenous retroviruses in murine embryonic stem cells and early embryos

X Lu - Journal of Molecular Cell Biology, 2023 - academic.oup.com
Endogenous retroviruses (ERVs) are important components of transposable elements that
constitute∼ 40% of the mouse genome. ERVs exhibit dynamic expression patterns during …

Human endogenous retroviruses and toll-like receptors

X Jin, X Li, F Guan, J Zhang - Viral Immunology, 2023 - liebertpub.com
Human endogenous retroviruses (HERVs) are estimated to comprise∼ 8% of the entire
human genome, but the vast majority of them remain transcriptionally silent in most normal …

[HTML][HTML] Human Endogenous Retroviruses and Their Putative Role in Pathogenesis of Alzheimer's Disease, Inflammation, and Senescence

P Kozubek, J Kuźniar, M Czaja, H Sitka, U Kochman… - Biomedicines, 2024 - mdpi.com
The human endogenous retroviruses (HERVs) are ancient exogenous retroviruses that were
embedded in the germline over 30 million years ago and underwent an endogenization …

What role do endogenous retroviruses play in domestic cats infected with feline leukaemia virus?

MC Canto-Valdés, ME Bolio González… - New Zealand …, 2023 - Taylor & Francis
Feline leukaemia virus (FeLV) is a retrovirus that infects domestic and wild cats around the
world. FeLV infection is associated with the development of neoplasms, bone marrow …