[HTML][HTML] Cheminformatics-based study identifies potential ebola VP40 inhibitors

E Broni, C Ashley, J Adams, H Manu, E Aikins… - International Journal of …, 2023 - mdpi.com
The Ebola virus (EBOV) is still highly infectious and causes severe hemorrhagic fevers in
primates. However, there are no regulatorily approved drugs against the Ebola virus disease …

Anti-biofilm: Machine learning assisted prediction of IC50 activity of chemicals against biofilms of microbes causing antimicrobial resistance and implications in drug …

A Rajput, KT Bhamare, A Thakur, M Kumar - Journal of Molecular Biology, 2023 - Elsevier
Biofilms are one of the leading causes of antibiotic resistance. It acts as a physical barrier
against the human immune system and drugs. The use of anti-biofilm agents helps in …

[HTML][HTML] Artificial Intelligence, machine learning, and big data for Ebola virus drug discovery

SK Kwofie, J Adams, E Broni, KS Enninful, C Agoni… - Pharmaceuticals, 2023 - mdpi.com
The effect of Ebola virus disease (EVD) is fatal and devastating, necessitating several efforts
to identify potent biotherapeutic molecules. This review seeks to provide perspectives on …

[HTML][HTML] Computational study on potential novel anti-Ebola virus protein VP35 natural compounds

LKS Darko, E Broni, DSY Amuzu, MD Wilson, CS Parry… - Biomedicines, 2021 - mdpi.com
Ebola virus (EBOV) is one of the most lethal pathogens that can infect humans. The Ebola
viral protein VP35 (EBOV VP35) inhibits host IFN-α/β production by interfering with host …

EBOLApred: A machine learning-based web application for predicting cell entry inhibitors of the Ebola virus

J Adams, K Agyenkwa-Mawuli, O Agyapong… - … Biology and Chemistry, 2022 - Elsevier
Ebola virus disease (EVD) is a highly virulent and often lethal illness that affects humans
through contact with the body fluid of infected persons. Glycoprotein and matrix protein VP40 …

[HTML][HTML] Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing

S Gautam, A Thakur, A Rajput, M Kumar - Viruses, 2023 - mdpi.com
Dengue outbreaks persist in global tropical regions, lacking approved antivirals,
necessitating critical therapeutic development against the virus. In this context, we …

Targeted Computational Approaches to Identify Potential Inhibitors for Nipah Virus

S Gautam, M Kumar - Current Trends in Computational Modeling for Drug …, 2023 - Springer
Nipah virus (NiV) is a bat-borne, highly pathogenic RNA virus belonging to the family
Paramyxoviridae. It is known for causing lethal encephalitis in humans with a high fatality …

Identification of Novel Inhibitors and Biomarkers for Alzheimer's Disease using Computational Systems Polypharmacology and Machine Learning Approach

R Shukla, TR Singh - 2022 - ir.juit.ac.in
The current research is focused on the management of the pathophysiology of the
Alzheimer's Disease (AD). The AD is a neurological irreversible disease characterized by …

[PDF][PDF] Computational Study on Potential Novel Anti-Ebola Virus Protein VP35 Natural Compounds. Biomedicines 2021, 9, 1796

LKS Darko, E Broni, DSY Amuzu, MD Wilson, CS Parry… - 2021 - academia.edu
Ebola virus (EBOV) is one of the most lethal pathogens that can infect humans. The Ebola
viral protein VP35 (EBOV VP35) inhibits host IFN-α/β production by interfering with host …