The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

Abstract The PRoteomics IDEntifications (PRIDE, http://www. ebi. ac. uk/pride) database at
the European Bioinformatics Institute is one of the most prominent data repositories of mass …

NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form,
NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced …

Markers are needed to facilitate early detection of pancreatic ductal adenocarcinoma
(PDAC), which is often diagnosed too late for effective therapy. Starting with a PDAC cell …

Although protein expression is regulated both temporally and spatially, most proteins have
an intrinsic," typical" range of functionally effective abundance levels. These extend from a …

Compared to other data‐intensive disciplines such as genomics, public deposition and
storage of MS‐based proteomics, data are still less developed due to, among other reasons …

Abstract The 19th annual Database Issue of Nucleic Acids Research features descriptions of
92 new online databases covering various areas of molecular biology and 100 papers …

Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by
behavioral alterations and currently affect about 1% of children. Significant genetic factors …

During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall
kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would …