The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …

Lung cancer is the leading cause of cancer death worldwide. Cancer metastasis and
resistance to treatment (including radiotherapy, chemotherapy and targeted therapy) are two …

Background The epithelial–mesenchymal transition (EMT) is crucial for the invasion and
metastasis of breast cancer. However, how Notch signaling regulates the EMT process and …

Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …

MicroRNAs (miRNAs or miR) have been integrated into tumorigenic programs as either
oncogenes or tumor suppressor genes. The miR-124 was reported to be attenuated in …

There is a growing interest to understand the role and mechanism of action of microRNAs
(miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that …

The process of epithelial–mesenchymal transition (EMT) which is required for cancer cell
invasion is regulated by a family of E-box–binding transcription repressors, which include …

The epithelial–mesenchymal transition (EMT) is a crucial developmental process by which
epithelial cells undergo a mesenchymal phenotypic change. During EMT, epigenetic …

Epithelial cancer cells are likely to undergo epithelial–mesenchymal transition (EMT) prior to
entering the peripheral circulation. By undergoing EMT, circulating tumor cells (CTCs) lose …

Melatonin, an indolamine mostly synthesized in the pineal gland, exerts the anti-cancer
effect by various mechanisms in glioma cells. Our previous study showed that miR-155 …