Vascular inflammation and oxidative stress: major triggers for cardiovascular disease

S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

[HTML][HTML] All-in-one bioactive properties of photothermal nanofibers for accelerating diabetic wound healing

Y Zhao, C Tian, Y Liu, Z Liu, J Li, Z Wang, X Han - Biomaterials, 2023 - Elsevier
Diabetic wound healing has attracted widespread attention in biomedical engineering.
However, the harsh hypoxic microenvironment (HME) comprising high glucose levels, local …

M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment

S Liu, J Chen, J Shi, W Zhou, L Wang, W Fang… - Basic research in …, 2020 - Springer
The roles and the underlying mechanisms of M1-type macrophages in angiogenesis and
postmyocardial infarction (MI) cardiac repair have remained unclear. In this study, we …

[HTML][HTML] AMPK and NRF2: Interactive players in the same team for cellular homeostasis?

E Petsouki, SNS Cabrera, EH Heiss - Free Radical Biology and Medicine, 2022 - Elsevier
NRF2 (Nuclear factor E2 p45‐related factor 2) is a stress responsive transcription factor
lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults …

[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies

A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …

AMPK, metabolism, and vascular function

C Rodríguez, M Muñoz, C Contreras… - The FEBS …, 2021 - Wiley Online Library
Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

[HTML][HTML] AMP-activated protein kinase: A remarkable contributor to preserve a healthy heart against ROS injury

A Marino, DJ Hausenloy, I Andreadou… - Free Radical Biology …, 2021 - Elsevier
Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

The sex-dependent response to psychosocial stress and ischaemic heart disease

TJ Helman, JP Headrick, NJC Stapelberg… - Frontiers in …, 2023 - frontiersin.org
Stress is an important risk factor for modern chronic diseases, with distinct influences in
males and females. The sex specificity of the mammalian stress response contributes to the …

Mitigation of aircraft noise-induced vascular dysfunction and oxidative stress by exercise, fasting, and pharmacological α1AMPK activation: molecular proof of a …

M Kvandová, S Rajlic, P Stamm, I Schmal… - European Journal of …, 2023 - academic.oup.com
Aims Environmental stressors such as traffic noise represent a global threat, accounting for
1.6 million healthy life years lost annually in Western Europe. Therefore, the noise …