Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …

Patients with diabetes are over-represented among the total cases reported with “idiopathic”
pulmonary fibrosis (IPF). This raises the question, whether this is an association only or …

Skeletal muscle insulin resistance is the earliest defect in type 2 diabetes (T2D), preceding
and predicting disease development. To what extent this reflects a primary defect or is …

The accumulation of DNA damage induced by oxidative stress is a crucial pathogenic factor
of endothelial loss in diabetic vascular complications, but it is still unknown whether aberrant …

Insulin resistance is present in one-quarter of the general population, predisposing these
people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of …

We investigated plasma microRNA (miRNA) profiles associated with variation of
hyperglycemia, measured as hemoglobin A1c (HbA1c), in two panels of patients with type 1 …

Background Despite recent advances in research, there are still critical lacunae in our basic
understanding of the cause, pathogenesis, and natural history of many cancers, especially …

Background In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative
stress are important pathogenic mechanisms causing end organ damage, including diabetic …

Diabetes‐associated organ fibrosis, marked by elevated cellular senescence, is a growing
health concern. Intriguingly, the mechanism underlying this association remained unknown …

The directed differentiation of human pluripotent stem cells, such as embryonic stem cells
(hESC s) and induced pluripotent stem cells (hi PSC s), into pancreatic endocrine lineages …