Kallikrein-related peptidases constitute a single family of 15 (chymo) trypsin-like proteases
(KLK1–15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been …

Human tissue kallikreins (KLKs) are attracting increased attention due to their role as
biomarkers for the screening, diagnosis, prognosis, and monitoring of various cancers …

Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of
androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone …

Human tissue kallikreins (KLKs or kallikrein-related peptidases) are a subgroup of
extracellular serine proteases that act on a wide variety of physiological substrates, while …

Early diagnosis of cancer and early detection of relapse following surgery are critical for the
effective treatment of the disease and for a positive clinical outcome. Identification of novel …

Background: Kallikrein-related peptidases (KLKs) are a family of serine proteases that have
been shown to be dysregulated in several malignancies including ovarian cancer. The …

Purpose: Human tissue kallikreins are a family of 15 secreted serine proteases. We have
previously shown that the expression of several tissue kallikreins is significantly altered at …

Abstract Kallikrein 4 (KLK4) is a member of the human tissue KLK family. Whereas all other
KLKs are secreted proteins with extracellular functions, KLK4 is primarily localized to the …

Human tissue kallikreins (KLKs) are the largest family of secreted serine protease
endopeptidases encoded by 15 genes clustered on chromosome 19q13. 4. Multiple KLK …

Human kallikrein-related peptidases (KLKs) are (chymo)-trypsin-like serine proteinases that
are expressed in a variety of tissues such as prostate, ovary, breast, testis, brain, and skin …