Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. With an
incidence rate of 3.19 per 100,000 persons in the United States and a median age of 64 …

Background Glioblastoma (GBM) is the most common and aggressive malignant brain tumor
in adults. Current treatment options at diagnosis are multimodal and include surgical …

Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here,
we interrogated N 6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA …

We test the hypothesis that glioblastoma harbors quiescent cancer stem cells that evade anti-
proliferative therapies. Functional characterization of spontaneous glioblastomas from …

Brain tumors are among the most lethal and devastating cancers. Their study is limited by
genetic heterogeneity and the incompleteness of available laboratory models. Three …

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as
nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system …

The macrophage is known to be a multifunctional antigen presenting cells and playing a
central role in inflammation. Macrophages infiltrate into malignant tumor tissues in high …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Despite extensive study, few therapeutic targets have been identified for glioblastoma
(GBM). Here we show that patient-derived glioma sphere cultures (GSCs) that resemble …

Glioblastoma multiforme is the most common primary malignant brain tumour, with a median
survival of about one year. This poor prognosis is due to therapeutic resistance and tumour …