Once a rarely used subset of medical treatments, protein therapeutics have increased
dramatically in number and frequency of use since the introduction of the first recombinant …

Objective: To determine the effects of “prolonged” antiplatelet therapy (that is, given for one
month or more) on “vascular events”(non-fatal myocardial infarctions, non-fatal strokes, or …

A doença cardíaca isquêmica, principal determinante da PCR, continua liderando as
causas de morte no mundo, e no Brasil não é diferente. 1, 2 Em 2013, nos Estados Unidos …

1.1. Methodology and Evidence Review The recommendations listed in this document are,
whenever possible, evidence based. The current document constitutes a full revision and …

Objectives: To propose standardized consensus definitions for important clinical endpoints
in transcatheter aortic valve implantation (TAVI), investigations in an effort to improve the …

Background The relative efficacy of streptokinase and tissue plasminogen activator and the
roles of intravenous as compared with subcutaneous heparin as adjunctive therapy in acute …

I present methods for assessing the relative effectiveness of two treatments when they have
not been compared directly in a randomized trial but have each been compared to other …

To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …

Abbreviations: ACT activated clotting time; APTT activated partial thromboplastin time; AT
antithrombin; AT-III antithrombin III; CI confidence interval; DVT deep vein thrombosis; GP …

Free radical oxidative stress has been implicated in the pathogenesis of a variety of human
diseases. Natural antioxidant defences have been found to be defective in many of the same …