Abstract Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal
antibodies with precise targeting and payloads with efficient killing, show great clinical …

In recent years, antibody-drug conjugates (ADCs) have become promising antitumor agents
to be used as one of the tools in personalized cancer medicine. ADCs are comprised of a …

Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2. 2.22)
that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs …

In cancer treatment, polymeric nanoparticles (NPs) can serve as a vehicle for the delivery of
cytotoxic proteins that have intracellular targets but that lack well-defined mechanisms for …

The conventional cancer therapeutic modalities include surgery, chemotherapy and
radiotherapy. Although immunotherapy and targeted therapy are also widely used in cancer …

Molecular farming in plants is an emerging platform for the production of pharmaceutical
proteins, and host species such as tobacco are now becoming competitive with …

Inspired by the immune system's own strategy for macrophage activation, we describe here
a simple self-assembly strategy for generating artificial immune complexes. The built-in …

Hepatocellular carcinoma (HCC) remains a leading malignancy with a high mortality and
little improvement in treatments. Protein drugs though known for their extraordinary potency …

Streptavidin-Saporin can be considered a type of 'secondary'targeted toxin. The scientific
community has taken advantage of this conjugate in clever and fruitful ways using many …

Targeted toxins (TT) for cancer treatment are a class of hybrid biologic comprised of a
targeting domain coupled chemically or genetically to a proteinaceous toxin payload. The …