Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Histone posttranslational modifications (HPTMs) are crucial epigenetic mechanisms
regulating various biological events. Different types of HPTMs characterize and shape …

Purpose: Bromodomain and extraterminal (BET) proteins are key epigenetic transcriptional
regulators, inhibition of which may suppress oncogene expression. We report results from 2 …

Triple-negative breast cancers (TNBCs) are aggressive tumors that are more common in
young women, African American populations, and those with hereditary mutations. These …

Purpose: NF-κB, a transcription factor essential for inflammatory responses, is constitutively
activated in many lymphomas. In preclinical studies, pelabresib (CPI-0610), an …

The Bromodomain and Extra Terminal (BET) family of proteins recognize post-translational
N-ε-acetylated lysine modifications, regulating transcription as “reader” proteins …

Bromodomain and extraterminal domain (BET) proteins have evolved as key multifunctional
super-regulators that control gene expression. These proteins have been shown to …

Selectivity is a crucial property in small molecule development. Binding site comparisons
within a protein family are a key piece of information when aiming to modulate the selectivity …

Abstract Treatment of cancer is now in a phase of new possibilities, and with the targeted
therapy, the advancement of the therapy is considered as the next generation of cancer …

Simple Summary The outcome for women diagnosed with ovarian cancer (OC), the most
aggressive gynecological tumor worldwide, remains very poor. Encouraging therapeutic …