The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …

Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

The repair of chromosomal double strand breaks (DSBs) is crucial for the maintenance of
genomic integrity. However, the repair of DSBs can also destabilize the genome by causing …

Multiple DNA polymerases participate in replicating the leading and lagging strands of the
eukaryotic nuclear genome. Although 50 years have passed since the first DNA polymerase …

DNA polymerase δ (Pol δ) and DNA polymerase ɛ (Pol ɛ) are both required for efficient
replication of the nuclear genome, yet the division of labor between these enzymes has …

In S. cerevisiae, the chromatin structure of DNA replication origins changes as cells become
competent for DNA replication, suggesting that G1 phase-specific association of replication …

The human genome encodes at least 14 DNA-dependent DNA polymerases—a surprisingly
large number. These include the more abundant, high-fidelity enzymes that replicate the …

This review discusses recent insights in the roles of DNA polymerases (Pol) δ and∊ in
eukaryotic DNA replication. A growing body of evidence specifies Pol∊ as the leading strand …

At the eukaryotic DNA replication fork, it is widely believed that the Cdc45–Mcm2–7–GINS
(CMG) helicase is positioned in front to unwind DNA and that DNA polymerases trail behind …

DNA polymerases synthesize DNA in only one direction, but large genomes require RNA
priming and bidirectional replication from internal origins. We review here the physical …