Interactions with host defences are key aspects of viral infection. Various viral proteins
perform counter-defensive functions, but a distinct class, called security proteins, is …

New protein-coding genes can originate either through modification of existing genes or de
novo. Recently, the importance of de novo origination has been recognized in eukaryotes …

The genus Cardiovirus (family Picornaviridae) currently comprises the species
Encephalomyocarditis virus (EMCV) and Theilovirus. Cardioviruses have a positive-sense …

The L* protein encoded by Theiler's murine encephalomyelitis virus (TMEV) is a unique
example of a picornaviral protein encoded by an alternative open reading frame. This …

Theiler's murine encephalomyelitis virus (TMEV) is a member of the Cardiovirus genus of
the Picornaviridae family. Interest in TMEV is at least partly related to the fact that the Daniels …

The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis
virus (TMEV) induce an early transient subclinical neuronal disease followed by a chronic …

L* protein of TMEV is out-of-frame with the viral polyprotein from an alternative initiation
codon AUG, 13 nucleotides downstream from the authentic polyprotein AUG. Anti-apoptotic …

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system.
Therapeutics that promote OL survival and remyelination are needed to restore neurological …

Theiler's original (TO) subgroup strains of Theiler's murine encephalomyelitis virus (TMEV)
cause a milder polioencephalomyelitis followed by virus persistence and demyelination in …

Viruses in the family Picornaviridae are classified into nine genera. Within the family
Picornaviridae, two species: Encephalomyocarditis virus and Theilovirus, are listed under …