The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid organs,
but the source (s) of extracellular S1P and whether S1P directly promotes egress are …

Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is …

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that is critically involved in the
embryonic development of the cardiovascular and central nervous systems. In the adult, S1P …

The egress of lymphocytes from the thymus and secondary lymphoid organs into circulatory
fluids is essential for normal immune function. The discovery that a small-molecule inhibitor …

The splenic marginal zone is a site of blood flow, and the specialized B cell population that
inhabits this compartment has been linked to the capture and follicular delivery of blood …

Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …

Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation within both the scientific and public sectors. β-Lactam …

The sphingosine 1-phosphate (S1P) receptor signaling system is a productive model
system. A hydrophobic zwitterionic lysophospholipid ligand with difficult physical properties …