Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

Ibrutinib is an orally administered inhibitor of Bruton tyrosine kinase that antagonizes B-cell
receptor, chemokine, and integrin-mediated signaling. In early-phase studies, ibrutinib …

Background Phosphatidylinositol-3-kinase delta (PI3Kδ) mediates B-cell receptor signaling
and microenvironmental support signals that promote the growth and survival of malignant B …

Chronic Lymphocytic Leukemia Treatment of CLL, the most common leukemia in the West,
has undergone a revolution in the past few years with the development of agents that target …

Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured
with standard rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R …

Purpose Survival and progression of mature B-cell malignancies depend on signals from the
B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in this …

Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely
to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted …

In a phase 1 trial, idelalisib (GS-1101, CAL-101), a selective inhibitor of the lipid kinase
PI3Kδ, was evaluated in 54 patients with relapsed/refractory chronic lymphocytic leukemia …

To gain insight into the genomic basis of diffuse large B-cell lymphoma (DLBCL), we
performed massively parallel whole-exome sequencing of 55 primary tumor samples from …