Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from
the inside to the outside of bacterial cells, contributing to bacterial multidrug resistance …

The antimicrobial resistance crisis is a global health issue requiring discovery and
development of novel therapeutics. However, conventional screening of natural products or …

Unique coumarin conjugates with thiazolidinone as novel structural antibacterial modulators
were exploited to combat the lethal multidrug-resistant bacterial infections. Bioactivity …

The increasing incidence of antibiotic resistance has forced the development of unique
antimicrobials with novel multitargeting mechanisms to combat infectious diseases caused …

Soil is recognized as the major reservoir of antibiotic resistance genes (ARGs), harboring
the most diverse naturally evolved ARGs on the planet. Multidrug resistance genes are a …

Providing an introduction to medicinal chemistry, this resource covers basic principles and
background, and describes the general tactics and strategies involved in developing an …

The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Biotechnological production in bacteria enables access to numerous valuable chemical
compounds. Nowadays, advanced molecular genetic toolsets, enzyme engineering as well …

Antibiotic resistance is a significant public health issue, causing illnesses that were once
easily treatable with antibiotics to develop into dangerous infections, leading to substantial …