Targeting SARS-CoV-2 papain-like protease in the postvaccine era
While vaccines remain at the forefront of global healthcare responses, pioneering
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
therapeutics against SARS-CoV-2 are expected to fill the gaps for waning immunity. Rapid …
Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone
H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
[HTML][HTML] Phytocompounds as potential inhibitors of SARS-CoV-2 Mpro and PLpro through computational studies
The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main
protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications; these viral …
protease (Mpro) and papain-like protease (PLpro) prevents viral multiplications; these viral …
[HTML][HTML] An overview of potential inhibitors targeting non-structural proteins 3 (PLpro and Mac1) and 5 (3CLpro/Mpro) of SARS-CoV-2
F Yan, F Gao - Computational and structural biotechnology journal, 2021 - Elsevier
There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …
Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World
The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …
Viral proteases as targets for coronavirus disease 2019 drug development
W Zhu, Z Shyr, DC Lo, W Zheng - Journal of Pharmacology and …, 2021 - ASPET
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), continues to be a global threat since its emergence. Although …
coronavirus 2 (SARS-CoV-2), continues to be a global threat since its emergence. Although …
[HTML][HTML] Co-crystallization and structure determination: An effective direction for anti-SARS-CoV-2 drug discovery
Z Wang, L Yang, XE Zhao - Computational and Structural Biotechnology …, 2021 - Elsevier
Safer and more-effective drugs are urgently needed to counter infections with the highly
pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient …
pathogenic SARS-CoV-2, cause of the COVID-19 pandemic. Identification of efficient …
[HTML][HTML] Natural and semi-synthetic flavonoid anti-SARS-CoV-2 agents for the treatment of long COVID-19 disease and neurodegenerative disorders of cognitive …
The aim of this review is to highlight the beneficial attributes of flavonoids, a diverse family of
widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue …
widely-distributed polyphenolic phytochemicals that have beneficial cell and tissue …
Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies
Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease
outbreak, there has been an increasing interest in discovering potential therapeutic agents …
outbreak, there has been an increasing interest in discovering potential therapeutic agents …
Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19
G Vere, MR Alam, S Farrar, R Kealy, BM Kessler… - Biomolecules, 2022 - mdpi.com
Ubiquitylation and ISGylation are protein post-translational modifications (PTMs) and two of
the main events involved in the activation of pattern recognition receptor (PRRs) signals …
the main events involved in the activation of pattern recognition receptor (PRRs) signals …