The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Aberrant c‐Met activity has been implicated in the development of hepatocellular carcinoma
(HCC), suggesting that c‐Met inhibition may have therapeutic potential. However, clinical …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

AMP-activated protein kinase (AMPK) regulates autophagy initiation when intracellular ATP
level decreases. However, the role of AMPK during autophagosome maturation is not fully …

Lysosomal dysfunction lies at the centre of the cellular mechanisms underlying Parkinson's
disease although the precise underlying mechanisms remain unknown. We investigated the …

Significance: Alterations in adipose tissue function have profound consequences on whole
body energy homeostasis because this tissue is central for fat accumulation, energy …

Since the rediscovery of active brown and beige adipose tissues in humans a decade ago,
great efforts have been made to identify the mechanisms underlying the activation and …

Abstract Glucocorticoid-induced osteoporosis (GIOP), one of the most common and serious
adverse effects associated with glucocorticoid administration, manifests as decreased bone …

Bile acids are microbial metabolites that can impact infection of enteric and hepatitis viruses,
but their functions during systemic viral infection remain unclear. Here we show that …

Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the
most common malignant myeloid disorder in adults. Several gene mutations such as in …