Increasing use of chimeric antigen receptor T-cell therapy (CAR-T) has unveiled diverse
toxicities warranting specific recognition and management. Cytopenias occurring after CAR …

G-CSF is a major extracellular regulator of haemopoiesis and the innate immune system.
Named for its relatively specific stimulation of the growth of neutrophil progenitor cells in vitro …

BACKGROUND Chimeric antigen receptor (CAR)‐modified “designer” T cells (dTc, CAR‐T)
against PSMA selectively target antigen‐expressing cells in vitro and eliminate tumors in …

Myeloid-derived suppressor cells (MDSCs) are newly identified immature myeloid cells that
are characterized by the ability to suppress immune responses and expand during cancer …

Granulocyte colony-stimulating factor (G-CSF) is a cytokine most well-known for maturation
and mobilization of bone marrow neutrophils. Although it is used therapeutically to treat …

In recent years, several investigators have unraveled a previously unrecognized role for G-
CSF in the regulation of T cell and dendritic cell functions. The experimental evidence in …

Autologous hematopoietic stem cell transplantation (aHSCT) is a highly effective treatment
of multiple sclerosis (MS). It depletes autoreactive cells and subsequently renews adaptive …

RA is an autoimmune disease characterized by sustained imbalance between pro-and
antiinflammatory immune mechanisms. The SOCS proteins are negative regulators of …

The recent shift to the use of stem cells mobilized by granulocyte colony-stimulating factor (G-
CSF) for hematopoietic transplantation has increased chronic graftversus-host disease …

Objectives: Autologous haematopoietic stem cell transplantation (HSCT) with CD34+ cell
selection has recently been used in the treatment of refractory Crohn's disease, showing …