Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …

Because of the high research and development cost of new drugs, the long development
process of new drugs, and the high failure rate at later stages, combining past drugs has …

Physiologically-based pharmacokinetics (PBPK) modeling is a robust tool that supports drug
development and the pharmaceutical industry and regulatory authorities. Implementation of …

Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …

ABSTRACT Introduction Adverse drug reactions (ADRs) are among the leading causes of
death, and frequently associated with drug–gene interactions (DGIs). In addition to …

The insidious nature of Zika virus (ZIKV) infections can have a devastating consequence for
fetal development. Recent reports have highlighted that chloroquine (CQ) is capable of …

Introduction Artemisinin-based combination therapies (ACTs) are recommended first-line
antimalarials for uncomplicated Plasmodium falciparum malaria. Pharmacokinetic …

Natural medicine has been widely used for clinical treatment and health care in many
countries and regions. Additionally, extracting active ingredients from traditional Chinese …

We investigated the acute and chronic effects of efavirenz, a widely used antiretroviral drug,
and CYP2B6 genotypes on the disposition of racemic and stereoisomers of bupropion …

Background: The clinical outcomes of antiretroviral drugs may be modified through drug
interactions; thus, it is important to update the drug interactions in people living with HIV …