Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1)
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …

The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation
channel that is chemically activated by capsaicin, the pungent component of hot peppers. In …

Objective To investigate the involvement of transient receptor potential ankyrin 1 (TRPA1) in
inflammatory hyperalgesia mediated by tumor necrosis factor α (TNFα) and joint …

Introduction: With 336 reviews, the capsaicin receptor TRPV1 arguably represent today's
most extensively reviewed analgesic target. TRPV1 is strategically located at the peripheral …

Key points The functional roles of the capsaicin receptor, TRPV1, outside of sensory nerves
are unclear. We mapped TRPV1 in the mouse circulation, revealing extensive expression in …

The transient receptor potential vanilloid 1 (TRPV1) is primarily localized to sensory nerve
fibers and is associated with the stimulation of pain and inflammation. TRPV1 knockout …

Background and aims Transient receptor potential vanilloid type 1 channel (TRPV1) is found
to be expressed in endothelial cells (ECs) and activate endothelial nitric oxide synthase …